Guidance documents
WHO Manual on the treatment of diarrhea
in English: The treatment of diarrhoea: A manual for physicians and other senior health workers.
in French: Le traitement de la diarrhée: Manuel à l’usage des médecins et autres personnels de santé qualifiés.
in Russian: The treatment of diarrhoea: A manual for physicians and other senior health workers (Russian).
in Chinese: The treatment of diarrhoea: A manual for physicians and other senior health workers (Chinese).
Implementing the new recommendations on the clinical management of diarrhea
in English: Implementing the new recommendations on the clinical management of diarrhea.
in Russian: Implementing the new recommendations on the clinical management of diarrhea (Russian).
Diarrhea treatment guidelines
in English: Diarrhea treatment guidelines. Including new recommendations for the use of ORS and zinc supplementation.
WHO / UNICEF joint statement on diarrhea treatment
in English: WHO/UNICEF joint statement: Clinical management of acute diarrhoea
in French: Déclaration commune de l’OMS et de l’UNICEF: Prise en charge clinique de la diarrhée aiguë
in Spanish: Declaración conjunta de la OMS y el UNICEF: Tratamiento clínico de la diarrea aguda
Guidelines on integrated management of childhood illness
Technical updates of the guidelines on integrated management of childhood illness (IMCI)
Guidelines for the control of shigellosis
Guidelines for the control of shigellosis, including epidemics due to Shigella dysenteriae type 1
Low risk of adverse effects from zinc supplementation
Low risk of adverse effects from zinc supplementation
Formative research manual provided by INCLEN
izincg technical document
Haider BA, Bhutta ZA. The effect of therapeutic zinc supplementation among young children with selected infections: A review of the evidence. Food Nutr Bull. 2009 Mar;30(1 Suppl):S41-59.
systematic reviews
Khan DSA, Naseem R, Salam RA, Lassi ZS, Das JK, Bhutta ZA. Interventions for High-Burden Infectious Diseases in Children and Adolescents: A Meta-analysis. Pediatrics. 2022 May 1;149(Suppl 5):e2021053852C.
Lazzerini M, Wanzira H. Oral zinc for treating diarrhoea in children. Cochrane Database Syst Rev. 2016 Dec 20;12:CD005436.
Lamberti LM, Walker CL, Chan KY, Jian WY, Black RE. Oral zinc supplementation for the treatment of acute diarrhea in children: a systematic review and meta-analysis. Nutrients. 2013 Nov 21;5(11):4715-40.
Fischer Walker CL, Black RE. Zinc for the treatment of diarrhoea: effect on diarrhoea morbidity, mortality and incidence of future episodes. Int J Epidemiol. 2010 Apr;39 Suppl 1:i63-9.
Patel A, Mamtani M, Dibley MJ, Badhoniya N, Kulkarni H. Therapeutic value of zinc supplementation in acute and persistent diarrhea: a systematic review. PLoS One. 2010 Apr 28;5(4):e10386.
Lukacik M, Thomas RL, Aranda JV. A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea. Pediatrics. 2008 Feb;121(2):326-36.
Aggarwal R, Sentz J, Miller MA. Role of zinc administration in prevention of childhood diarrhea and respiratory illnesses: a meta-analysis. Pediatrics. 2007 Jun;119(6):1120-30.
Bhutta ZA, Bird SM, Black RE, Brown KH, Gardner JM, Hidayat A, et al. Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials. Am J Clin Nutr. 2000 Dec;72(6):1516-22.